文献类型：期刊文献

中文题名：苯甲酰脲类化合物的合成及杀虫活性

英文题名：Synthesis and Insecticidal Activity of Benzoylphenylurea Derivatives

作者：张文文[1];郑震[1];彭延庆[1];徐晓勇[1];李忠[1]

机构：[1]上海市化学生物学重点实验室,华东理工大学药学院,上海200237

年份：2009

卷号：11

期号：1

起止页码：36

中文期刊名：农药学学报

外文期刊名：Chinese Journal of Pesticide Science

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金(20502006,2087203);上海市科委和教委资助项目(073919107,064319022,B507)

语种：中文

中文关键词：HBr—H2O2溴代体系;绿色合成;苯甲酰脲;昆虫生长调节剂

外文关键词：H2O2/HBr bromination system; green synthesis; benzoylurea; insect growth regulator

摘要：对2-氨基-5-芳基-1,3,4口-恶二唑的合成进行了深入研究,找到了一种基于HBr-H2O2体系的绿色合成新方法,并以此为中间体,合成了18个未见报道的苯甲酰脲类目标化合物,所有化合物均通过核磁共振、高分辨质谱、红外光谱的分析鉴定。生物活性测试结果表明,在500mg/L浓度下该系列目标化合物均未表现出显著的杀虫活性。
A cleaner approach to 2-amino-5-aryl-1,3,4-oxadiazoles,a series of benzoylphenylurea intermediates were developed and optimized by using HBr-H2O2 system as an alternative to molecular bromine.Eighteen novel benzoylphenylurea compounds were synthesized starting from 2-amino-5-aryl-1,3,4-oxadiazoles,and were identified by ^1H NMR,HRMS and IR spectra.However,no remarkable insecticidal activity was observed during bioassay.