文献类型：期刊文献

英文题名：Spatio-Temporally Reporting Dose-Dependent Chemotherapy via Uniting Dual-Modal MRI/NIR Imaging

作者：Ma, Yiyu[1,2];Yan, Chenxu[1,2];Guo, Zhiqian[1,2];Tan, Guang[1,2];Niu, Dechao[3];Li, Yongsheng[3];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Sci Ctr Mat & Dynam Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Sci Ctr Mat & Dynam Chem, Inst Fine Chem Joint Int Res Lab Precis Chem & Mo, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2020

卷号：59

期号：47

起止页码：21143

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20203709156543);WOS:【SCI-EXPANDED(收录号:WOS:000566548700001)】；

基金：This work was supported by NSFC/China (21788102, 21636002, 21622602, 21878087, and 21908060), National Key Research and Development Program (2016YFA0200300), the Innovation Program of Shanghai Municipal Education Commission, Shuguang Program (18SG27), China Postdoctoral Science Foundation (2019M651417), and Fundamental Research Funds for the Central Universities. This study was performed in strict accordance with the NIH guidelines for the care and use of laboratory animals (NIH Publication No. 85-23 Rev. 1985) and was approved by the Institutional Animal Care and Use Committee of National Tissue Engineering Center (Shanghai, China).

语种：英文

外文关键词：assembly nanotheranostics; chemodynamic therapy; fluorescent probes; magnetic resonance imaging; near-infrared dual-channel

摘要：Unpredictable in vivo therapeutic feedback of hydroxyl radical ((OH)-O-.) efficiency is the major bottleneck of chemodynamic therapy. Herein, we describe novel Fenton-based nanotheranostics NQ-Cy@Fe&GOD for spatio-temporally reporting intratumor(.)OH-mediated treatment, which innovatively unites dual-channel near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces the dose distribution of Fenton-based iron oxide nanoparticles (IONPs) with high-spatial resolution, meanwhile timely fluorescence signal quantifies(.)OH-mediated therapeutic response with high spatio-temporal resolution. NQ-Cy@Fe&GOD can successfully monitor the intracellular release of IONPs and(.)OH-induced NQO1 enzyme in living cells and tumor-bearing mice, which makes a breakthrough in conquering the inherent unpredictable obstacles on spatio-temporally reporting chemodynamic therapy, so as to manipulate dose-dependent therapeutic process.