文献类型：期刊文献

中文题名：Construction of highly accessible single Co site catalyst for glucose detection

英文题名：构建单位点Co催化剂用于葡萄糖检测

作者：Can Xiong[1,2];Lin Tian[2];Chunchun Xiao[3];Zhenggang Xue[2];Fangyao Zhou[2];Huang Zhou[2];Yafei Zhao[2];Min Chen[2];Qiuping Wang[2];Yunteng Qu[2];Yidong Hu[1,2];Wenyu Wang[2];Yan Zhang[2];Xiao Zhou[2];Zhiyuan Wang[1,2];Peiqun Yin[1,2];Yu Mao[5];Zhen-Qiang Yu[1];Yueqiang Cao[4];Xuezhi Duan[4];Lei Zheng[5];Yuen Wu[2]

机构：[1]School of Chemistry and Environmental Engineering,Institute of Low-dimensional Materials Genome Initiative,Shenzhen University,Shenzhen 518060,China;[2]School of Chemistry and Materials Science,Hefei National Laboratory for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei 230026,China;[3]The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China;[4]State Key Laboratory of Chemical Engineering,East China University of Science and Technology,Shanghai 200237,China;[5]School of Food and Biological Engineering,Hefei University of Technology,Hefei 230009,China

年份：2020

卷号：65

期号：24

起止页码：2100

中文期刊名：Science Bulletin

外文期刊名：科学通报（英文版）

收录：Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：This work was supported by the Postdoctoral Science Foundation of China (2019M653052), the Fundamental Research Funds for the Central Universities (WK2060120002), the National Key R&D Program of China (2017YFA, 0208300), and the National Natural Science Foundation of China (21671180). This fabrication of SGGT devices was performed at the USTC Center for Micro and Nanoscale Research and Fabrication. We sincerely thank the photoemission endstations beamline 1W1B station in Beijing Synchrotron Radiation Facility (BSRF), BL10B and BL11U in National Synchrotron Radiation Laboratory (NSRL) in Hefei, China.

语种：英文

中文关键词：Glucose sensor;Sensitivity;Selectivity;Single site catalyst;Solution-gated graphene transistor

外文关键词：葡萄糖传感器;生物传感器;葡萄糖检测;灵敏度提高;个性化医疗;糖尿病诊断;替代方法;监测方法;

摘要：The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and their noninvasive alternatives largely suffered from the relatively poor sensitivity, selectivity, and stability, resulted from the lack of robust and efficient catalysts. In this paper, we design a concave shaped nitrogen-doped carbon framework embellished with single Co site catalyst(Co SSC) by selectively controlling the etching rate on different facet of carbon substrate, which is beneficial to the diffusion and contact of analyte. The Co SSC prompts a significant improvement in the sensitivity of the solutiongated graphene transistor(SGGT) devices, with three orders of magnitude better than those of SGGT devices without catalysts. Our findings expand the field of single site catalyst in the application of biosensors, diabetes diagnostics and personalized health-care monitoring.
开发高性能的葡萄糖传感器是迫切需要的,特别是对于糖尿病诊断.目前,葡萄糖监测方法仍采用传统的有创式指尖取血,无创的替代方法由于缺乏高效和鲁棒的催化剂,面临着灵敏度低、选择性差和稳定性弱等难题.本文通过选择性地控制碳基体不同面的蚀刻速率,构建了Co单位点修饰的凹形氮掺杂碳骨架,这种凹陷的骨架有利于分析物的扩散和接触.单位点Co催化剂(Co SSC)显著提高了溶液栅控石墨烯晶体管(SGGT)器件的灵敏度,将无催化剂修饰的SGGT器件的灵敏度提高了2个数量级.本发现拓展了单位点催化剂在生物传感器、糖尿病诊断和个性化医疗监测等领域中的应用.