文献类型：期刊文献

英文题名：Biomaterials Act as Enhancers of Growth Factors in Bone Regeneration

作者：Chen, Rui[1,2];Wang, Jing[1,2];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2016

卷号：26

期号：48

起止页码：8810

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20164703037903);WOS:【SCI-EXPANDED(收录号:WOS:000391812700002)】；

基金：The authors are indebted to the financial support from the National Natural Science Foundation of China (No. 31330028, No. 31470923, and No. 31271011), National Basic Research Program of China (973 Program, No. 2012CB933600), Major Basic Research Foundation of Shanghai Science and Technique Committee (14JC1490800), and Shanghai International Incorporation Program (155207111000). This study is also supported by New Century Excellent Talents in University (No. NCET-12-0856) and 111 Project (B14018).

语种：英文

外文关键词：biomaterials; bone regeneration; bone morphogenetic proteins; growth factors; scaffolds

摘要：Inspired by the physiological events of the wound healing cascade, the integration of biomaterials and growth factors is generally accepted as an emerging and powerful strategy for bone regenerative therapy. As a type of biological mediator, growth factors play a key role in functional bone regeneration. In this review, recent progress in the enhancement of bone-related growth factors via a biomaterial strategy will be discussed. Two main reinforcing mechanisms, temporal regulation and efficacy manipulation, are described in detail, highlighting the potential capability of biomaterials to harness the interactions between growth factors and specific cells. The effects of biomaterials for promoting bone formation via growth factor-mediated osteogenesis are further elucidated. Finally, an outlook of the prospects in terms of superior communication among growth factors, cells, and biomaterials in the microenvironment is presented, which might provide new directions for the design of medical devices for bone regeneration.