文献类型：期刊文献

英文题名：Chain entanglement-driven tough, fatigue-resistant PEG-based injectable hydrogel adhesive for joint skin wound healing

作者：Wang, Kun[1];Zhang, Yi[1];Chen, Tianhao[1];Bai, Long[2];Li, Haihang[3];Tan, Haoqi[4];Liu, Changsheng[1];Qu, Xue[1,5,6,7]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China;[3]Sichuan Univ, Coll Biomed Engn, Chengdu 610065, Sichuan, Peoples R China;[4]Suzhou Innovat Ctr Shanghai Univ, Shanghai Univ, Suzhou 215000, Jiangsu, Peoples R China;[5]Shanghai Univ, Wenzhou Inst, Wenzhou 325000, Peoples R China;[6]Shanghai Frontier Sci Ctr Optogenet Tech Cell Meta, Shanghai 200237, Peoples R China;[7]East China Univ Sci & Technol, 130 Meilong Rd, Shanghai, Peoples R China

年份：2023

卷号：266

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20233814737036);WOS:【SCI-EXPANDED(收录号:WOS:001146030400001)】；

基金：This work was supported by the National key research and development program (2021YFB3800800) , the National Natural Science Foundation of China (31922041, 11932012, 32171341, 82202334) , the 111 project (B14018) , the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee (21S31901500, 21XD1421100) are acknowledged.

语种：英文

外文关键词：Injectable hydrogel adhesives; Entanglement effect; Elastic and tough; Joint skin wound dressing

摘要：The development of effective wound dressings that can withstand the frequent movement and stretching of joint skin wounds remains a significant challenge. Traditional wound dressings are prone to damage or shedding, which increases the risk of bacterial infection and delays wound healing. To address this issue, a new type of injectable, stretchable, low hysteresis, and fatigue-resistant hydrogel (LZM/PEG) adhesive has been designed for wound healing in movable parts. The hydrogel is formed through the flexible chain entanglement of high molecular weight polyethylene glycol functionalized by Succinimide Carbonate (SC-PEG-SC) and Amidation crosslinking between LZM-NH2 and SC-PEG-SC. The long-chain of SC-PEG-SC enables the hydrogel to penetrate the surface of the target tissue, generating physical entanglements and covalent bonds with functional groups in the matrix, enabling close fitting of joint skin and wound healing without the need of secondary fixation. In a neck trauma model of full-thickness skin defect in vivo, the hydrogel dressing significantly promoted wound healing with milder inflammation, higher granulation tissue thickness and collagen disposition, demonstrating its potential for joint skin wound treatment in clinics. Overall, the LZM/PEG hydrogel is capable of adapting to the frequent movement of joint, promoting healing of joint skin wounds, which makes it a promising approach for joint skin wound treatment.