文献类型：期刊文献

英文题名：Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions

作者：Jiang, Jian-An[1];Chen, Cheng[1];Huang, Jian-Gang[1];Liu, Hong-Wei[1];Cao, Song[1];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：16

期号：3

起止页码：1248

外文期刊名：GREEN CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000332039200034)，CCR-EXPANDED(收录号:WOS:000332039200034)】；

基金：We gratefully acknowledge the National Natural Science Foundation of China (Project No. 21176074) for its financial support.

语种：英文

摘要：A hindered para-hydroxyl group-directed remote benzylic C(sp(3))-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcohols and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds. The ligandand additive-free Cu(OAc)(2)-catalyzed atmospheric oxidation mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodology is expected to be of significant value for both fundamental research and practical applications.