文献类型：期刊文献

英文题名：Residues around the catalytic pocket of DdsA are important for isoprenoids chain elongation

作者：Liu, Xinyi; Yuan, Qinsheng; Zhang, Huizhan

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2007

卷号：14

期号：1

起止页码：27

外文期刊名：PROTEIN AND PEPTIDE LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000245376700005)】；

语种：英文

外文关键词：decaprenyl diphosphate synthase; ubiquinone; site-directed mutagenesis

摘要：Nineteen mutants of decaprenyl diphosphate synthase from Gluconobacter suhoxydans were generated and their production of ubiquinones (UQs) was compared to that of the wild type protein. The accessible surface area and the polarity of amino acid around the catalytic pocket wield remarkable influences on the isoprenoid chain elongation of UQs.