文献类型：期刊文献

英文题名：Regulation of inflammatory response to polyglycolic acid scaffolds through incorporation of sodium tripolyphosphate

作者：Zhang, Jiapeng[1];Song, Chaobo[1];Han, Yuqing[1];Xi, Zhenhao[1,2];Zhao, Ling[1,2];Cen, Lian[1];Yang, Ying[3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai, Peoples R China;[2]Shanghai Huaming HiTech Grp Co LTD, Natl Engn Res Ctr Ultrafine Powder, Shanghai, Peoples R China;[3]Univ Keele, Inst Sci & Technol Med, Stoke On Trent, Staffs, England

年份：2020

卷号：122

外文期刊名：EUROPEAN POLYMER JOURNAL

收录：;EI(收录号：20194807742366);WOS:【SCI-EXPANDED(收录号:WOS:000509784900039)】；

基金：The authors are grateful to the National Natural Science Foundation of China (Grant No. 21676083), the Shanghai Rising-Star Program (Grant No. 16QB140130), the Fundamental Research Funds for the Central Universities (Grant No. 22221818014), the 111 Project (Grant No. B08021) and the Taicang Outstanding Academic Leader Program. The authors also appreciate the experimental support and suggestion from Shanghai Key Laboratory of Orthopaedic Implant in Shanghai Ninth People's Hospital.

语种：英文

外文关键词：Polyglycolide; TPP; Composite scaffolds; Strong acidity; Cytokines; Immunocompetent animals

摘要：Polyglycolic acid (PGA) is a typical polyester with successful clinical and commercial applications. It causes severe host response and needs modification according to clinical cases. The expression of the pro-healing cytokine, IL-10, from macrophages as indicators of immune-response to PGA medical devices can be the key to be revealed. We thereby intended to modify PGA to affect its degradation profile and modulate the secretion of cytokines by macrophages. Sodium tripolyphosphate (TPP) was incorporated into PGA scaffolds as fillers via a scCO(2) foaming process. A porcine subcutaneous model was further employed to evaluate the inflammation and the expression profiles of macrophages (IL-10 and IL-1 beta as well as their phenotypes) in these implants. It was shown that IL-1 beta and IL-6 were both inhibited in vitro in PGA and PGA-TPP groups without dependence on pH. The secretion of TNF-alpha was stimulated when pH was 6.1 and was inhibited by acidosis with pH of 3.6. IL-10 was also suppressed when pH was 3.6. In vivo expression of IL-1 beta was increased in both groups. However, IL-10 exhibited higher values in PGA-TPP group than in PGA one, although a decreasing trend appeared in PGA-TPP implants from the 2nd to the 4th week. The infiltration of leukocytes was still severe in PGA scaffolds after two weeks post-surgery, while this was evidently relieved in PGA-TPP ones. In summary, the incorporation of TPP into PGA implants could be an efficient way to relief the inflammatory response and to improve the clinical outcomes of translational polyester implants.