文献类型：期刊文献

英文题名：Effects of ambient air pollution from municipal solid waste landfill on children's non-specific immunity and respiratory health

作者：Yu, Yunjiang[1];Yu, Ziling[1];Sun, Peng[3];Lin, Bigui[1];Lu, Liangzhong[1];Wang, Zhengdong[1];Ma, Ruixue[1];Xiang, Mingdeng[1];Li, Hui[2];Guo, Shu[1]

机构：[1]Minist Environm Protect, South China Inst Environm Sci, State Environm Protect Key Lab Environm Pollut Hl, Guangzhou 510655, Guangdong, Peoples R China;[2]East China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[3]China Inst Atom Energy, Beijing 102413, Peoples R China

年份：2018

卷号：236

起止页码：382

外文期刊名：ENVIRONMENTAL POLLUTION

收录：;EI(收录号：20180604763246);WOS:【SCI-EXPANDED(收录号:WOS:000429187500040)】；

基金：Financial support has received from the National Natural Science Foundation of China (U1401233 and 21377045) and the Basic Research Foundation of National Commonwealth Research Institute (No. PM-zx703-201602-042). The authors are grateful anonymous reviewers for helpful comments on the manuscript.

语种：英文

外文关键词：Municipal solid waste (MSW) landfill; Secretory immunoglobulin A (SIgA); Salivary lysozyme; Lung function; Children

摘要：This cross-sectional study investigated the association between air pollutant (AP) and respiratory health of 951 children residing near a municipal solid waste (MSW) landfill in Northern China. Results showed that students in non-exposure areas had significantly higher levels of lysozyme, secretory immunoglobulin A (SIgA), and better lung capacity than students in exposure areas (p <.05). Multiple regression model analysis indicated that lysozyme levels exhibited a consistent negative association with methane (CH4: beta= -76.3, 95% CI -105 to -47.7) and sulfuretted hydrogen (H2S: beta= -11.7, 95% CI -20.2 to -3.19). In addition, SIgA levels were negatively associated with H2S (beta = -68.9, 95% CI -97.9 to -39.9) and ammonia (NH3: beta= -30.3, 95% CI -51.7 to -8.96). Among all AP, H2S and sulfur dioxide (SO2) were the most robustly related with reduced lung function. H2S exposure was negatively associated with six lung function indices, 1-s forced expiratory volume (FEV1%), mean forced expiratory flow between 25% and 75% (MMF), maximum voluntary ventilation (MW), and forced expiratory flow at 25%, 50%, and 75% of the pulmonary volume (FEF25, FEF50, FEF75); and SO2 was negatively associated with FEV1%, MW, FEF25, FEF50 and FEF75. Our results suggested that AP exposure was negatively associated with more lung function parameters in boys than in girls. In conclusion, our findings suggested that children living adjacent to landfill sites were more likely to have deficient non-specific immunity and impaired lung function. (C) 2017 Elsevier Ltd. All rights reserved.