文献类型：期刊文献

英文题名：Celastrol as a tool for the study of the biological events of metabolic diseases

作者：Lan, Gongcai[1,2];Zhang, Jie[2];Ye, Wenbo[3];Yang, Fan[2,4];Li, Ang[3,5];He, Weiwei[2,5];Zhang, Wei-Dong[1,2,4]

机构：[1]Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China;[4]Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China;[5]Jiangxi Qingfeng Pharmaceut Co Ltd, State Key Lab Innovat Nat Med & Tradit Chinese Me, Ganzhou 341000, Peoples R China

年份：2019

卷号：62

期号：4

起止页码：409

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20191106614206);WOS:【SCI-EXPANDED(收录号:WOS:000463714600004)】；

基金：This work was supported by Professor of Chang Jiang Scholars Program, the National Natural Science Foundation of China (81520108030, 21472238, 81502956, 21572064, 21525209, 21621002, 21772225, 21761142003), Chinese Academy of Sciences (Strategic Priority Research Program XDB20000000 and Key Research Program of Frontier Sciences QYZDB-SSW-SLH040), Shanghai Science and Technology Commission (15JC1400400, 17XD1404600), the National Program for Support of Top-Notch Young Professionals of China, the K. C. Wong Education Foundation, and the State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections (QFSKL2017003, QFSKL2017004).

语种：英文

外文关键词：celastrol; obesity; type 2 diabetes; endoplasmic reticulum stress; inflammation

摘要：Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been used in traditional Chinese medicine for treating rheumatoid arthritis. Previous studies showed that celastrol possessed diverse biological activities, including anti-inflammatory and anticancer properties. Interestingly, most recent literatures revealed the important role of celastrol against metabolic disorders. Herein, we provide an overview of the modes of action of celastrol for combating metabolic diseases such as obesity and type 2 diabetes. The anti-obesity effect of celastrol results from relieving endoplasmic reticulum stress in hypothalamus, regulating HSF1-PGC1 alpha axis in the adipose tissue and muscle, and alleviating inflammation via Nur77 mediated autophagy. Celastrol also reverses insulin resistance via NF-kappa B signaling pathway to protect against type 2 diabetes.