文献类型：期刊文献

英文题名：Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy

作者：Yan, Chenxu[1];Xu, Hongxia[2,3];Wu, Menglan[1];Zhao, Zijun[1];Zhao, Weijun[1];Tang, Jianbin[2,3];Guo, Zhiqian[1]

机构：[1]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Key Lab Adv Mat & Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Sch C, Shanghai 200237, Peoples R China;[2]Zhejiang Univ, Ctr Bionanoengn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou 310027, Peoples R China;[3]Zhejiang Univ, Dept Chem & Biol Engn, Hangzhou 310027, Peoples R China

年份：2021

卷号：64

期号：11

起止页码：2045

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20211210121471);WOS:【SCI-EXPANDED(收录号:WOS:000631331000002)】；

基金：This work was supported by the National Natural Science Foundation of China (21878087, 21908060), the Innovation Program of Shanghai Municipal Education Commission, Shuguang Program (18SG27). This study was performed in strict accordance with the NIH guidelines for the care and use of laboratory animals (NIH Publication No. 85-23 Rev. 1985) and was approved by the Institutional Animal Care and Use Committee of National Tissue Engineering Center (Shanghai, China).

语种：英文

外文关键词：fluorescence probe; near-infrared fluorescence probe; photoacoustic imaging; self-assembly; prodrug

摘要：Uniting dual-modality of fluorescence and photoacoustic (PA) imaging into theranostic nanoprobes is imperative for spatio-temporally tracking of drug delivery, distribution, and release. Herein, we present a rational design strategy of molecularly precise amphiphilic prodrugs BPn-Cy-S-CPT (n=0, 5, and 20, refers to the degree of polyethylene glycol (PEG) polymerization; CPT=camptothecin) to tune their self-assembly behaviour, innovatively integrating dual-modal PA and near-infrared (NIR) fluorescence imaging in a single-molecular framework. Among these elaborately designed prodrugs, it is found that only BP20-Cy-S-CPT could form uniform and highly stable self-assemblies, especially in showing synergistically enhanced PA and dualchannel NIR signals. In detail, PA signal is employed to trace the in vivo delivery with high spatial resolution, meanwhile the glutathione (GSH)-triggered dual-channel fluorescence response could real-timely monitor drug distribution and release without "blind spot". The results of in vivo dual-modal PANIR imaging have verified that BP20-Cy-S-CPT displayed synergistic targeting (including passive, active, and activatable targeting) for tumor-specific delivery, and thereby executed CPT release in the tumor site. Consequently, our molecularly precise BP20-Cy-S-CPT self-assemblies could make a breakthrough to spatio-temporally track the in vivo drug release profile, expanding the intelligent theranostic toolbox for precise cancer treatment.