文献类型：期刊文献

英文题名：Fabrication of PCL Scaffolds by Supercritical CO2 Foaming Based on the Combined Effects of Rheological and Crystallization Properties

作者：Song, Chaobo[1];Luo, Yunhan[1];Liu, Yankai[1];Li, Shuang[2];Xi, Zhenhao[1,3];Zhao, Ling[1,3];Cen, Lian[1];Lu, Eryi[2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Sch Chem Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Shanghai 200127, Peoples R China;[3]Xinjiang Univ, Coll Chem & Chem Engn, Urumqi 830046, Peoples R China

年份：2020

卷号：12

期号：4

外文期刊名：POLYMERS

收录：;EI(收录号：20202508858116);WOS:【SCI-EXPANDED(收录号:WOS:000535587700050)】；

基金：This research was funded by the National Natural Science Foundation of China (Grant No. 21676083), the National Key R&D Program of China (Grant No.2016YFB0302200), the Fundamental Research Funds for the Central universities (Grant No. 22221818010), the Science and Technology Commission of Shanghai Municipality (No 17140903400), the Opening Project of the Shanghai Key Laboratory of Orthopaedic Implants (KFKT2017001) and the Taicang Outstanding Academic Leader Program.

语种：英文

外文关键词：polycaprolactone (PCL); supercritical carbon dioxide (scCO(2)); tissue engineering; rheology; crystallization

摘要：Polycaprolactone (PCL) scaffolds have recently been developed via efficient and green supercritical carbon dioxide (scCO(2)) melt-state foaming. However, previously reported gas-foamed scaffolds sometimes showed insufficient interconnectivity or pore size for tissue engineering. In this study, we have correlated the thermal and rheological properties of PCL scaffolds with their porous morphology by studying four foamed samples with varied molecular weight (MW), and particularly aimed to clarify the required properties for the fabrication of scaffolds with favorable interconnected macropores. DSC and rheological tests indicate that samples show a delayed crystallization and enhanced complex viscosity with the increasing of MW. After foaming, scaffolds (27 kDa in weight-average molecular weight) show a favorable morphology (pore size = 70-180 mu m, porosity = 90% and interconnectivity = 96%), where the lowest melt strength favors the generation of interconnected macropore, and the most rapid crystallization provides proper foamability. The scaffolds (27 kDa) also possess the highest Young's modulus. More importantly, owing to the sufficient room and favorable material transportation provided by highly interconnected macropores, cells onto the optimized scaffolds (27 kDa) perform vigorous proliferation and superior adhesion and ingrowth, indicating its potential for regeneration applications. Furthermore, our findings provide new insights into the morphological control of porous scaffolds fabricated by scCO(2) foaming, and are highly relevant to a broader community that is focusing on polymer foaming.