文献类型：期刊文献

英文题名：A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery

作者：Cao, Hongliang[1,2];Chen, Chao[3,4];Xie, Debiao[1,2];Chen, Xin[1,2];Wang, Ping[3,4,5];Wang, Yibing[3,4];Song, Huajie[1,2];Wang, Wenxin[6]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Biotechnol, Shanghai, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Biomed Nanotechnol Ctr, Shanghai, Peoples R China;[5]Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA;[6]Univ Coll Dublin, Charles Inst Dermatol, Sch Med & Med Sci, Dublin, Ireland

年份：2018

卷号：9

期号：2

起止页码：169

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20175204588243);WOS:【SCI-EXPANDED(收录号:WOS:000418645100003)】；

基金：This work was supported by the Shanghai Leading Academic Discipline Project (B502), the Shanghai Key Laboratory Project (08DZ2230500), the National Natural Science Foundation of China (21303050, 31471659 and 21636003), the Fundamental Research Funds for the Central Universities (222201514327), the State Key Laboratory of Functional Materials for Informatics Open Project (SKL201306) and the Shanghai Pujiang Program (13PJ1401700). Authors thank the support from the Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM).

语种：英文

外文关键词：Block copolymers - Dendrimers - Controlled drug delivery - Lanthanum compounds - Targeted drug delivery - Atom transfer radical polymerization

摘要：Nanoparticles are appealing drug delivery systems since they promise prolonged circulation time and predictable release behaviors. The current work reports a novel hyperbranched amphiphilic block copolymer synthesized using deactivation-enhanced atom transfer radical polymerization (DE-ATRP) for smart drug delivery. PEG2000-Br was applied as a macroinitiator to initiate acid-cleavable divinyl (ACD) monomers linked by acetal groups, formulating the hydrophilic (PEG) and hydrophobic (ACD) segments. The polymer appeared to self-assemble into micelles with diameters in the range of 70-100 nm, and was examined for the controlled release of doxorubicin (DOX). Results showed that DOX-loaded micelles (similar to 90 nm) could achieve drug loading as high as 8.2 wt%, with interesting pH-dependent release behaviors. Studies with flow cytometry (FCM) and confocal laser scanning microscopy (CLSM) showed that DOX-loaded micelles exhibited a high cellular uptake performance by HeLa cells, which indicated promising antitumor efficacy for such a drug delivery system. Additionally, such DOX-loaded micelles exhibited remarkable cytotoxicity against HeLa cells in a dose-and time-dependent manner due to the enhanced cell uptake behavior of micelles. These results indicated that the polymeric micelles might be used as a promising candidate for a pH-responsive drug delivery for cancer therapy.