文献类型：期刊文献

英文题名：Electrochemically promoted tandem cyclization of functionalized methylenecyclopropanes: synthesis of tetracyclic benzazepine derivatives

作者：Li, Min[1,2];Wei, Yin[3];Shi, Min[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Chinese Acad Sci,State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2025

卷号：23

期号：17

起止页码：4166

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20251418184875);WOS:【SCI-EXPANDED(收录号:WOS:001456935900001)，CCR-EXPANDED(收录号:WOS:001456935900001)】；

基金：We are grateful for the financial support from the National Key R & D Program of China (2022YFC2303101), the National Natural Science Foundation of China (21372250, 21121062, 21302203, 20732008, 21772037, 21772226, 21861132014, 91956115, and 22171078), and the Fundamental Research Funds for the Central Universities 222201717003.

语种：英文

外文关键词：Cyclohexane

摘要：In this study, an electrocatalytic tandem cyclization reaction of amide-tethered methylenecyclopropanes has been developed, which can realize the rapid construction of tetracyclic benzazepine derivatives in moderate yields with good functional group compatibility under relatively mild conditions. In this transformation, the catalytic amount of ferrocene serves as the electrocatalytic medium, and electron transfer on electrodes can replace oxidants or reducing agents, which is more environmentally friendly than and economically comparable to traditional photocatalysis or metal catalysis. Moreover, the origin of the regiochemistry is well elucidated through density functional theory (DFT) calculations.