文献类型：期刊文献

英文题名：Evaluation of the biocompatibility of a nonceramic hydroxyapatite

作者：Liu, CS; Wang, WB; Shen, W; Chen, TY; Hu, LM; Chen, ZW

机构：[1]SHANGHAI MED UNIV,ZHONGSHAN HOSP,SHANGHAI 200032,PEOPLES R CHINA

年份：1997

卷号：23

期号：8

起止页码：490

外文期刊名：JOURNAL OF ENDODONTICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:A1997XN91500003)】；

语种：英文

摘要：In this study, the biocompatibility of calcium phosphate cement (CPC) was systematically investigated, which included systemic injection acute toxicity assay, cell culture cytotoxicity assay, gene mutation assay (Ames test), chromosome aberration assay (micronucleus test), DNA damage assay (unscheduled DNA synthesis test) and implant histological evaluation. The results showed that the CPC had no toxicity and all tests for mutagenicity and potential carcinogenicity of CPC extracts are negative. CPC was implanted into the femurs of rabbits under no-load condition and the histology of specimens revealed that the implant tightly joined with the surrounding bone, only a very slight histological inflammatory reaction occurred. Thus, CPC is a highly biocompatible material and seems to be safe for application in humans.