文献类型：期刊文献

英文题名：Study of the relationship between the target tissue necrosis volume and the target tissue size in liver tumours using two-compartment finite element RFA modelling

作者：Zhang, Bing[1,2];Moser, Michael A. J.[3];Zhang, Edwin M.[4];Luo, Yigang[3];Zhang, Hongbo[1];Zhang, Wenjun[1,2,5]

机构：[1]E China Univ Sci & Technol, Sch Mech & Power Engn, Complex & Intelligent Syst Ctr, Shanghai 200237, Peoples R China;[2]Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada;[3]Univ Saskatchewan, Dept Surg, Saskatoon, SK S7N 5A9, Canada;[4]Univ Alberta, Dept Radiol & Diagnost Imaging, Edmonton, AB, Canada;[5]Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada

年份：2014

卷号：30

期号：8

起止页码：593

外文期刊名：INTERNATIONAL JOURNAL OF HYPERTHERMIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000345705000008)】；

基金：This article was supported by the Saskatchewan Health Research Foundation (SHRF) through the 'BioNEMS Phase I' (grant no. 2539). This article was also supported by the National Natural Science Foundation of China (grant no. 51175179). The first author (Bing Zhang) also received financial support from the China Scholarship Council (CSC). Special thanks go to the anonymous reviewers' comments on this paper, which helped to improve the paper considerably.

语种：英文

外文关键词：Finite element analysis; Liver tumour; radiofrequency ablation; roll-off occurrence; target tissue necrosis

摘要：Purpose: The aim of this study was to investigate the relationship between the target tissue necrosis volume and the target tissue size during the radiofrequency ablation (RFA) procedure. Materials and methods: The target tissues with four different sizes (d(xy) = 20, 25, 30 and 35 mm) were modelled using a two-compartment radiofrequency ablation model. Different voltages were applied to seek the maximum target tissue necrosis volume for each target tissue size. The first roll-off occurrence or the standard ablation time (12 min) was taken as the sign for the termination of the RFA procedure. Results: Four different maximum voltages without the roll-off occurrence were found for the four different sizes of target tissues (d(xy) = 20, 25, 30 and 35 mm), and they were 36.6, 35.4, 33.9 and 32.5 V, respectively. The target tissues with diameters of 20, 25mm can be cleanly ablated at their own maximum voltages applied (MVA) but the same finding was not found for the 35-mm target tissue. For the target tissue with diameter of 30 mm, the 50 degrees C isothermal contour (IT50) result showed that the target tissue can be cleanly ablated, but the same result did not show in the Arrhenius damage model result. Furthermore, two optimal RFA protocols with a minimal thermal damage to the healthy tissues were found for the target tissues with diameters of 20 and 25 mm, respectively. Conclusions: The study suggests that target tissues of different sizes should be treated with different RFA protocols. The maximum target tissue volume was achieved with the MVA without the roll-off occurrence for each target tissue size when a constant RF power supply was used.