文献类型：期刊文献

中文题名：粉防己根的化学成分研究

英文题名：Chemical Constituents from the Roots of Stephania tetrandra

作者：刘顺[1,2];李姚婷[1];沈思懿[1];翁伟宇[2];康云[1];黄建明[1];汪亚勤[1]

机构：[1]复旦大学药学院,上海201203;[2]华东理工大学药学院,上海200237

年份：2022

卷号：45

期号：6

起止页码：1368

中文期刊名：中药材

外文期刊名：Journal of Chinese Medicinal Materials

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；PubMed;

语种：中文

中文关键词：粉防己;化学成分;生物碱

外文关键词：Stephania tetrandra S.Moore;Chemical constituents;Alkaloids

摘要：目的:研究粉防己根的化学成分。方法:采用大孔树脂、硅胶、Sephadex LH-20葡聚糖凝胶、ODS柱色谱等方法对粉防己根的70%乙醇提取物进行分离纯化,根据理化性质及波谱数据进行结构鉴定。结果:从粉防己根中分离得到11个化合物,分别鉴定为:(-)-oblongine(1)、fordianoside(2)、乌药碱(3)、荷包牡丹碱(4)、木兰花碱(5)、N,N-dimethyllindcarpine(6)、防己菲碱(7)、N-trans-feruloyl tyramine(8)、4-羟基苯乙醇-4-O-β-D-吡喃葡萄糖苷(9)、粉防己碱(10)、防己诺林碱(11)。结论:其中,化合物2、3、6、8、9为首次从粉防己中分离得到。
Objective:To study the chemical constituents from the roots of Stephania tetrandra.Methods:The 70%ethanol extract from the roots of Stephania tetrandra was isolated and purified by column chromatography over macroporous resin,silica gel,Sephadex LH-20,ODS.The structures of the compounds were identified by physicochemical properties and spectral data.Results:Eleven compounds were isolated from the roots of Stephania tetrandra and identified as(-)-oblongine(1),fordianoside(2),coclaurine(3),dicentrine(4),magnoflorine(5),N,N-dimethyllindcarpine(6),stephenanthrine(7),N-trans-feruloyl tyramine(8),4-hydroxyphenethylol-4-O-β-D-glucopyranoside(9),tetrandrine(10),fangchinoline(11),respectively.Conclusion:Among them,compounds 2,3,6,8,9 are isolated from Stephania tetrandra for the first time.