文献类型：期刊文献

中文题名：载药妥布霉素人工骨(磷酸钙骨水泥)修复骨缺损的动物试验

英文题名：An in Vivo Study of Tobramycin-Impregnated Calcium Phosphate Cement as an Artificial Bone Material Repairing Bone Defect

作者：王传军[1];陈统一[1];张键[1];刘昌胜[2]

机构：[1]复旦大学附属中山医院骨科,上海200032;[2]华东理工大学生物材料研究所,上海200237

年份：2001

卷号：28

期号：6

起止页码：473

中文期刊名：复旦学报（医学版）

外文期刊名：Fudan University Journal of Medical Sciences

收录：CSTPCD;;EI(收录号：2003387638594);Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

基金：上海市现代生物与新药产业发展基金(9943 192 0 3 )资助项目

语种：中文

中文关键词：磷酸钙骨水泥;妥布霉素;组织学;骨缺损;修复

外文关键词：Biodegradation;Calcium compounds;Histology

摘要：目的　评价自固化磷酸钙骨水泥CPC(calciumphosphatecement)载药妥布霉素及植入兔体内后的CPC生物降解特性。方法　把CPC棒和妥布霉素CPC药棒植入兔股骨 ,观察其界面组织学等变化。结果　通过 3个月观察 ,发现CPC棒和CPC药棒有部分被吸收现象 ,并且药棒中有新骨形成。
Purpose: To evaluate the bidegradability of the tobramycin - impregnated self-setting calcium phosphate cement (CPC) after planted into rabbits' bodies. Methods: We observed the histological and other changes of the interface between bone and cement after CPC bars and drug-loaded CPC bars were implanted into the femora of rabbits. Results: Three months later the CPC and tobramycin-loaded CPC were partially obsorbed and new bone formed in bars. Conclusions: The drug-doaded CPC has bidegradability and osteoconductivity functions.