文献类型：期刊文献

英文题名：Nucleation kinetics of lovastatin in different solvents from metastable zone widths

作者：Zhang, Xiangyang[1,2]; Yang, Zhiqing[3]; Chai, Jian[3]; Xu, Jinyi[3]; Zhang, Liang[3]; Qian, Gang[1]; Zhou, Xinggui[1]

机构：[1] State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Product Engineering, East China University of Science and Technology, Shanghai, 200237, China; [3] Hisun Co. Ltd, Taizhou, China

年份：2015

卷号：133

起止页码：62

外文期刊名：Chemical Engineering Science

收录：EI(收录号：20150700518708)

语种：英文

外文关键词：Acetone - Methanol - Organic solvents - Ethanol - Kinetics - Activation energy

摘要：Cooling crystallization of lovastatin in methanol, ethanol and acetone was carried out and the metastable zone widths in those solutions were determined experimentally by the polythermal method using a Turbidity Monitoring Technique. Two theoretical approaches, the self-consistent approach and classical 3D nucleation theory approach, were then employed to estimate the nucleation kinetics from the measured metastable zone width. The results suggested that nucleation in ethanol and acetone is instantaneous and follows polynuclear (PN) mechanism, while in methanol the nucleation is progressive with a high nucleation order. Because of the high solubility of lovastatin in these solvents, strong solute–solvent interactions exist, which make the activation energy for crystal formation different from that for self-diffusion. ? 2015 Elsevier Ltd