文献类型：期刊文献

英文题名：3D-Printed Dual-Bionic Scaffolds to Promote Osteoconductivity and Angiogenesis for Large Segment Bone Restoration

作者：Chen, Bo[1,2];Chen, Qi[3,4];Zhang, Haodong[3,4];Zhang, Donghui[3,4];Li, Cuidi[1];Ma, Ke[3,4];Dou, Mengyue[3,4];Lu, William Weijia[2];Qi, Jin[1];Deng, Lianfu[1];Liu, Runhui[3,4,5];Cui, Wenguo[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Traumatol & Orthopaed,Ruijin Hosp, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China;[2]Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong 999077, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[5]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China

年份：2025

卷号：35

期号：17

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20245217597920);WOS:【SCI-EXPANDED(收录号:WOS:001383185900001)】；

基金：B.C. and Q.C. contributed equally to this work. This research was supported by the National Natural Science Foundation of China (No. T2325010, 32301124, 52361165622), Shanghai Municipal Health and Family Planning Commission (202340148), the Natural Science Foundation of Jiangsu Province (BK20243003), Science and Technology Commission of Shanghai Municipality (23015820800), the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences). The authors thank the Analysis and Testing Center of the East China University of Science and Technology for their help in the characterization. The authors thank the staff members of the Integrated Laser Microscopy System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab, China for providing technical support and assistance in data collection.

语种：英文

外文关键词：3D-printing; amino acid polymer; deferoxamine; dual-bionic scaffolds; large segment bone restoration

摘要：Large segment bone defects pose a significant challenge in the field of orthopedic surgery, requiring effective and innovative approaches for restoration. However, many existing scaffolds are bioinert and do not support crucial processes such as cell adhesion, proliferation, and vascularization. In this study, a dual-bionic 3D printing bredigite scaffold is developed, featuring a combination of physical structure and bioactive functions. Specifically, the structure-mimetic scaffold has an isotropic single-cell structure suitable for defects with varying load-bearing requirements and allowing the ingrowth of vessels and bone. Meanwhile, an extracellular matrix peptide-mimetic beta-amino acid polymer DM50CO50 and deferoxamine are modified onto the scaffold simultaneously to promote the adhesion of bone marrow mesenchymal stem cells and vascularization. The dual-bionic scaffolds demonstrate outstanding osteogenic and angiogenic properties in a rat model with large segment bone defects to promote bone restoration, implying a promising strategy in designing scaffolds to promote osteoconductivity and angiogenesis for large segment bone restoration.