文献类型：期刊文献

英文题名：Continuous-Flow Nanoprecipitation Method to Synthesize Degradable Hollow Mesoporous Organosilica Nanoparticles for Insecticide Delivery

作者：Fu, Zhinan[1];Ma, Enguang[2];Yang, Zheng[1];Li, Li[1];Guo, Xuhong[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Dezhou Univ, Coll Chem & Chem Engn, Shandong Prov Key Lab Monocrystalline Silicon Semi, Dezhou, Peoples R China

年份：2023

卷号：39

期号：41

起止页码：14718

外文期刊名：LANGMUIR

收录：;EI(收录号：20234515042580);WOS:【SCI-EXPANDED(收录号:WOS:001078937800001)】；

基金：The authorswould like to acknowledge the China ScholarshipCouncil (CSC) for financial support. This work is also supported bythe Key Scientific and Technological Project of Xinjiang Bingtuan(2018AB025).

语种：英文

外文关键词：Controlled drug delivery - Photolysis - Silica - Synthesis (chemical) - Targeted drug delivery - Temperature

摘要：Degradable mesoporous organosilica nanoparticles (MONPs) are attracting significant attention in the area of designing smart drug carriers mainly due to their excellent stability and multiple functions. However, the efficient, controllable, and large-scale production of MONPs still faces huge challenges. Herein, a novel and facile continuous-flow nanoprecipitation strategy was reported to synthesize hollow MONPs with highly uniform and tailored properties. The synthesized hollow MONPs possessed a large surface area (S-BET > 1070.1 m(2) g(-1)), narrow size distribution, large hollow cavity, and thin shell. Interestingly, the incorporation of organic moieties into silica cross-linked networks led to the timely degradation of nanocarriers with the desired responsiveness. Moreover, the applicability of the as-obtained hollow MONPs has been demonstrated in the loading and pH-responsive release of thiamethoxam (THI). The resultant THI-loaded MONPs possessed long-term storage stability at a low temperature and showed release behaviors in response to a basic environment. Benefiting from the shielding property of MONPs, THI-loaded MONPs manifested superior stability against the photolysis as compared to that of the THI technical. This work provides a new consideration for promoting the advancement of nanotechnology in agricultural fields.