文献类型：期刊文献

英文题名：Ultrasensitive Chemodynamic Therapy: Bimetallic Peroxide Triggers High pH-Activated, Synergistic Effect/H2O2 Self-Supply-Mediated Cascade Fenton Chemistry

作者：Zhou, Hao[1];Li, Xiaowei[1];Niu, Dechao[2];Li, Yongsheng[2];Liu, Xiaohang[3];Li, Chengfeng[1];Si, Weimeng[1];Cao, Jun[1];Song, Yuanda[4];Wen, Guangwu[1];Niu, Zhihui[5];Zhang, Lijuan[1]

机构：[1]Shandong Univ Technol, Sch Mat Sci & Engn, Inst Engn Ceram, Zibo 255000, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]Fudan Univ, Shanghai Canc Ctr, Dept Radiol, Shanghai 200032, Peoples R China;[4]Shandong Univ Technol, Colin Ratledge Ctr Microbial Lipids, Sch Agr Engn & Food Sci, Zibo 255000, Peoples R China;[5]Shandong Univ Technol, Sch Phys & Optoelect Engn, Inst Computat Phys, Zibo 255000, Peoples R China

年份：2021

卷号：10

期号：9

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20211010018360);WOS:【SCI-EXPANDED(收录号:WOS:000623176900001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 51802178, 51972112, and 21805171), the Natural Science Foundation of Shandong Province (Grant Nos. ZR2019BEM041 and ZR2020QB126), and the Shandong Provincial Key Research and Development Project (2019JZZY010440).

语种：英文

外文关键词：bimetallic peroxide; H2O2 self‐ supply; high pH‐ activated chemistry; synergistic enhanced chemistry; ultrasensitive chemodynamic therapy

摘要：Recently, nanoparticle-triggered in situ catalytic Fenton/Fenton-like reaction is widely explored for tumor-specific chemodynamic therapy (CDT). However, despite the great potential of CDT in tumor treatment, insensitive response to the relatively high pH of the tumor sites and the insufficient intratumoral H2O2 level leads to limited efficiency of most Fenton/Fenton-like reactions, which greatly imped its clinical conversion. This paper reports the fabrication of Fenton-type bimetallic peroxides for ultrasensitive chemodynamic therapy with high pH-activated, synergistic effect/H2O2 self-supply-mediated cascade Fenton chemistry for the first time. The observations reveal that these bimetallic peroxides exhibit an ultrasensitive acid-activated decomposition-mediated Fenton-like reaction at the relatively high pH of 6.5-7.0, accompanied with highly increased center dot OH generation efficiency (especially, 40-60-fold increase at pH 7.0) by the metal-mediated synergistic effect-enhanced Fenton chemistry as well as in situ self-generated H2O2 supplement. Moreover, the bimetallic peroxides exhibit high tumor accumulation which along with a high-efficiency tumor catalytic-therapeutic with negligible side effects in vivo. Developing these novel bimetallic peroxides, together with the already demonstrated capacity of the key metals (Fe, Mn, Cu, etc.) for magnetic resonance imaging or photodynamic/immune-enhanced therapy, will propel interest in development of smart high-efficiency nanoplatform for cancer theranostics.