文献类型：期刊文献

英文题名：Light-responsive polymersomes with a charge-switch for targeted drug delivery

作者：Zhou, Yaowu[1];Chen, Rongrong[1];Yang, Huiting[1];Bao, Chunyan[1];Fan, Jinyan[1];Wang, Chenxi[1];Lin, Qiuning[1];Zhu, Linyong[1]

机构：[1]East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ct, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2020

卷号：8

期号：4

起止页码：727

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20200608131136);WOS:【SCI-EXPANDED(收录号:WOS:000510754400010)】；

基金：This work is supported by the NSFC (Grant No. 21472044, 21425311), the National Key Research and Development Project (2019YFA0110500) and the Open Project of State Key Laboratory for Supramolecular Structure and Materials (SKLSSM 201901). The authors thank the Research Centre of Analysis and Test of East China University of Science and Technology for its help with the characterization.

语种：英文

外文关键词：Hydrophilicity - Controlled drug delivery - Organic acids - Disintegration - Lanthanum compounds

摘要：Unlike the traditional block amphiphilic polymersomes, we herein report a lipid-like amphiphilic polymer that self-assembles into photo-responsive polymersomes for drug delivery. The introduction of a quaternary ammonium moiety not only provides a hydrophilic segment of the polymersomes, but also enables electrostatic adsorption with folic acid, thus achieving the targeting of cancer cells with overexpression of folate receptor. Upon light irradiation, the photocleavage reaction of the o-nitrobenzyl moiety disintegrates polymersomes by changing the polymer structure from cationic amphiphilic state to zwitterionic hydrophilic state, thus realizing photo-triggered drug release. The data showed that anticancer drugs (doxorubicin hydrochloride, DOX center dot HCl) can be loaded into the hydrophilic cavity of polymersomes and controllably released by photo-induced disintegration of polymersomes. Cellular assay showed that the active targeting of folic acid and photo-triggered release endowed the DOX-loaded polymersomes with a higher cytotoxicity to HeLa cells. Such cationic polymersomes provide a novel strategy for designing effective and intelligent drug carriers, and have potential application as a novel integrated platform for targeted drug delivery.