文献类型：期刊文献

英文题名：Self-Amplified Photodynamic Therapy through the 1O2-Mediated Internalization of Photosensitizers from a Ppa-Bearing Block Copolymer

作者：Liu, Zhiyong[1]; Cao, Tianye[2,3]; Xue, Yudong[1]; Li, Mengting[2]; Wu, Mengsi[1]; Engle, Jonathan W.[2]; He, Qianjun[3]; Cai, Weibo[2]; Lan, Minbo[1]; Zhang, Weian[1]

机构：[1] Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China; [2] Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, United States; [3] Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for, Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen, Guangdong, 518060, China

年份：2020

卷号：59

期号：9

起止页码：3711

外文期刊名：Angewandte Chemie - International Edition

收录：EI(收录号：20200608128531)

语种：英文

外文关键词：Oxygen - Controlled drug delivery - Targeted drug delivery - Fluorescence imaging - Cancer cells - Photodynamic therapy - Photosensitizers

摘要：Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non-selective release of photosensitizers still exist. Herein, we report a 1O2-responsive block copolymer (POEGMA-b-P(MAA-co-VSPpaMA) to enhance PDT via the controllable release of photosensitizers. Once nanoparticles formed by the block copolymer have accumulated in a tumor and have been taken up by cancer cells, pyropheophorbide a (Ppa) could be controllably released by singlet oxygen (1O2) generated by light irradiation, enhancing the photosensitization. This was demonstrated by confocal laser scanning microscopy and in vivo fluorescence imaging. The 1O2-responsiveness of POEGMA-b-P(MAA-co-VSPpaMA) block copolymer enabled the realization of self-amplified photodynamic therapy by the regulation of Ppa release using NIR illumination. This may provide a new insight into the design of precise PDT. ? 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim