文献类型：期刊文献

英文题名：Catalytic enantioselective henry reactions of isatins: Application in the concise synthesis of (S)-(-)-spirobrassinin

作者：Liu, Lu[1]; Zhang, Shilei[1]; Xue, Fei[1]; Lou, Guangshun[1]; Zhang, Haoyi[1]; Ma, Shichao[1]; Duan, Wenhu[1,2]; Wang, Wei[1,2,3]

机构：[1] School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China; [2] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China; [3] Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, United States

年份：2011

卷号：17

期号：28

起止页码：7791

外文期刊名：Chemistry - A European Journal

收录：EI(收录号：20112614107554)

语种：英文

外文关键词：Chromatography - Catalysis

摘要：When isatin a cat! A highly efficient, cupreine-catalyzed, enantioselective Henry reaction of readily available isatins and nitroalkanes has been developed (see scheme). The products are produced in excellent yields and good enantioselectivities under mild reaction conditions and without chromatography. The utility of the strategy has been demonstrated in the facile synthesis of (S)-(-)-spirobrassinin without the need for protecting groups. Copyright ? 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.