文献类型：会议论文

英文题名：Ruthenium nitrosyl grafted carbon dots as a fluorescence-trackable nanoplatform for visible light-controlled nitric oxide release and targeted intracellular delivery

作者：Deng, Qiao[1];Xiang, Hui-Jing[1];Tang, Wei-Wei[1];An, Lu[2];Yang, Shi-Ping[2];Zhang, Qian-Ling[3];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Dept Chem, MOE, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, MOE, Key Lab Resource Chem, Shanghai 200234, Peoples R China;[3]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China

会议论文集：1st International Symposium on Clinical and Experimental Metallodrugs in Medicine - Cancer Chemotherapy (CEMM)

会议日期：DEC, 2015

会议地点：Honolulu, HI

语种：英文

外文关键词：Nitric oxide; Photo-release; Targeted delivery; Nanoplatform; Carbon dots; Ruthenium nitrosyl

摘要：Nitric oxide (NO) plays a key role in various physiological and pathological processes. It is of great significance in developing a platform that enables exogenous delivery of NO spatiotemporally to a targeted site for realizing NO mediated therapy. We report herein a stable, multifunctional NO-delivery nanoplatform that is capable of target directing, fluorescence tracking, and light-controlled NO delivery. A ruthenium nitrosyl [Ru(TPYCOOH(o-phenylenediamine)(NO)](PF6)(3) and a target-directing molecule of folic acid (FA) were covalently grafted onto the surface of a carrier of carbon dots (CDs), forming a {Ru-NO@FA@CDs} nanoplatform. This nanoplatform is fluorescence self-trackable in a cellular environment and can recognize specific cancer cells via FA-folate receptor binding; it was selectively taken up by cancer cells to enter the cytosol, in which localized NO was produced on demand by adept control of visible light illumination. This offered the potential for treating diseases derived from NO deficiency as well as NO-mediated cancer therapy. (C) 2016 Elsevier Inc. All rights reserved.