文献类型：期刊文献

英文题名：Recent Advancesand Prospects of Succinate DehydrogenaseInhibitor Acaricides

作者：Zhou, Cong[1];Gao, Zihang[1];Li, Zhong[1];Qian, Xuhong[1];Maienfisch, Peter[1,2];Cheng, Jiagao[1,3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]CreInSol MCB, CH-4118 Rodersdorf, Switzerland;[3]Guizhou Univ, State Key Lab Green Pesticide, Guiyang 550025, Peoples R China

年份：2026

卷号：74

期号：27

起止页码：20841

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20262921137776);Scopus(收录号：2-s2.0-105044953208);WOS:【SCI-EXPANDED(收录号:WOS:001812577500001)】；

基金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (22477029 and 22307039), the National Key Research and Development Program of China (2023YFD1700501), and the Shanghai Agriculture Applied Technology Development Program (T2024302).

语种：英文

外文关键词：acaricides; succinate dehydrogenaseinhibitor; mode of action; acaricide resistance

摘要：The development of acaricides with novel modes of action is of great significance for sustainable mite management, resistance mitigation, and long-term agricultural development. Succinate dehydrogenase (SDH) has recently emerged as a promising target for acaricide discovery, leading to the development of several key SDHI acaricides, including cyflumetofen, cyenopyrafen, cyetpyrafen, and pyflubumide. This review systematically summarizes the discovery and development of SDHI acaricides and current knowledge on metabolic and target-site mutation resistance mechanisms, as well as the potential toxicity toward nontarget organisms. These insights are expected to provide valuable guidance for the rational design of next-generation acaricides and practical application in environmentally friendly mite management.