文献类型：期刊文献

英文题名：A biodegradable, flexible photonic patch for in vivo phototherapy

作者：Deng, Kaicheng[1];Tang, Yao[2,3];Xiao, Yan[4];Zhong, Danni[5];Zhang, Hua[6];Fang, Wen[1];Shen, Liyin[1];Wang, Zhaochuang[4];Pan, Jiazhen[6];Lu, Yuwen[1];Chen, Changming[7];Gao, Yun[6];Jin, Qiao[6];Zhuang, Lenan[6];Wan, Hao[7];Zhuang, Liujing[7];Wang, Ping[7];Zhai, Junfeng[8];Ren, Tanchen[9];Hu, Qiaoling[1];Lang, Meidong[4];Zhang, Yue[10];Wang, Huanan[6];Zhou, Min[3,5,11,12];Gao, Changyou[1,13];Zhang, Lei[2,3];Zhu, Yang[1,14,15]

机构：[1]Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China;[2]Res Ctr Humanoid Sensing, Zhejiang Lab, Hangzhou 311100, Peoples R China;[3]Zhejiang Univ, Coll Opt Sci & Engn, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat Minist Educ, Shanghai 200237, Peoples R China;[5]Zhejiang Univ, Univ Edinburgh Inst, ZJU UoE Inst, Sch Med, Haining 314400, Peoples R China;[6]Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Peoples R China;[7]Zhejiang Univ, Dept Biomed Engn, Biosensor Natl Special Lab, Key Lab Biomed Engn Educ Minist, Hangzhou 310027, Peoples R China;[8]Chinese Acad Inspect & Quarantine, Inst Plant Quarantine, Beijing 100176, Peoples R China;[9]Zhejiang Univ, Affiliated Hosp 2, Dept Cardiol, Cardiovasc Key Lab Zhejiang Prov, Hangzhou 310009, Peoples R China;[10]San Francisco VA Med Ctr, San Francisco, CA 94121 USA;[11]Zhejiang Univ, Inst Translat Med, Hangzhou 310009, Peoples R China;[12]Zhejiang Univ, Key Lab Canc Prevent & Intervent, Natl Minist Educ, Hangzhou 310009, Peoples R China;[13]Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Regen, Hangzhou 310058, Peoples R China;[14]Zhejiang Univ, Binjiang Inst, Hangzhou 310053, Peoples R China;[15]Zhejiang Univ, Sir Run Run Shaw Hosp, Key Lab Cardiovasc Intervent & Regenerat Med Zheji, Hangzhou 310016, Peoples R China

年份：2023

卷号：14

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000996589500003)】；

基金：AcknowledgmentsThis study is financially supported by the National Key Research and Development Program of China (no. 2019YFE0117400), National Natural Science Foundation of China (no. 82202328, 32000971, 61975173, 32250008, 62271443, 81971667), Major Scientific Research Project of Zhejiang Lab (no. 2019MC0AD01), Key Research and Development Project of Zhejiang Province (no. 2021C05003), and Binjiang Institute of Zhejiang University (ZY202205SMKY007). The authors thank research staff Qiaojuan Shi from Zhejiang Academy of Medical Sciences for her assistance in animal studies, and Yuhang Tao from Sir Run Run Shaw Hospital for his assistance with electrocardiogram monitoring and analysis.

语种：英文

摘要：Diagnostic and therapeutic illumination on internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity remains a major challenge. Here, we present a flexible, biodegradable photonic device called iCarP with a micrometer scale air gap between a refractive polyester patch and the embedded removable tapered optical fiber. ICarP combines the advantages of light diffraction by the tapered optical fiber, dual refractions in the air gap, and reflection inside the patch to obtain a bulb-like illumination, guiding light towards target tissue. We show that iCarP achieves large area, high intensity, wide spectrum, continuous or pulsatile, deeply penetrating illumination without puncturing the target tissues and demonstrate that it supports phototherapies with different photosensitizers. We find that the photonic device is compatible with thoracoscopy-based minimally invasive implantation onto beating hearts. These initial results show that iCarP could be a safe, precise and widely applicable device suitable for internal organs and tissue illumination and associated diagnosis and therapy. Illuminating internal organs and tissues with high controllability and adaptability remains challenging. Here the authors present a flexible, biodegradable photonic device called iCarP for large area, high intensity, wide spectrum, deeply penetrating, continuous or pulsatile illumination.