文献类型：期刊文献

英文题名：An Efficient One-Pot Synthesis of Substituted 2-Aminothiophenes via Three-Component Gewald Reaction Catalyzed by L-Proline

作者：Wang, Tao[1,2];Huang, Xian-Gui[1,2];Liu, Jia[1,2];Li, Bo[4];Wu, Jin-Jin[1];Chen, Kai-Xian[4];Zhu, Wei-Liang[1,3];Xu, Xiao-Yong[1,2];Zeng, Bu-Bing[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China;[4]Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China

年份：2010

期号：9

起止页码：1351

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000278408800012)，CCR-EXPANDED(收录号:WOS:000278408800012)】；

基金：This work was financially supported by the Science & Technology Commission of Shanghai Municipality (064319022), 111 Project (B07023), the National '863' Project of China (2006AA609Z447) and (2007AA02Z301) and Shanghai Pujiang Program (05PJ14035).

语种：英文

外文关键词：Gewald reaction; 2-aminothiophene; one-pot; multi-component; Knoevenagel reaction

摘要：An efficient one-pot procedure for the direct catalytic synthesis of substituted 2-aminothiophenes catalyzed by L-proline under mild reaction conditions has been developed. A variety of functionalized 2-aminothiophene scaffolds were assembled in high yields by this catalytic protocol. Low catalyst loading, simple procedure, and high yields are the important attributes of this methodology.