文献类型：期刊文献

英文题名：Urethane-based low-temperature curing, highly-customized and multifunctional poly(glycerol sebacate)-co-poly(ethylene glycol) copolymers

作者：Wang, Zihao[1,3];Ma, Yifan[1,3];Wang, YanXiang[1,3];Liu, Yutong[1,3];Chen, Kai[1,3];Wu, Zihan[1,3];Yu, Shuang[1,3];Yuan, Yuan[1,3];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Engn Res Ctr Biomat, Minist Educ, Shanghai 200237, Peoples R China

年份：2018

卷号：71

起止页码：279

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20215111336851);WOS:【SCI-EXPANDED(收录号:WOS:000431470300023)】；

基金：The authors wish to express their gratitude to the financial supports from the National Natural Science Foundation of China for Innovative Research Groups (No.51621002), the National Natural Science Foundation of China (No.31330028 and 31470924), 111 Project (B14018) and the Fundamental Research Funds for the Central Universities (222201718002).

语种：英文

外文关键词：Supramolecular bioelastomer; Urethane-based PEGylated PGS; Low-temperature curing; Highly-customized; Multiple biomedical applications

摘要：Poly (glycerol sebacate) (PGS), a tough elastomer, has been widely explored in tissue engineering due to the desirable mechanical properties and biocompatibility. However, the complex curing procedure (high temperature and vacuum) and limited hydrophilicity (similar to 90 degrees of wetting angle) greatly impede its functionalities. To address these challenges, a urethane-based low-temperature setting, PEGylated PGS bioelastomer was developed with and without solvent. By simultaneously tailoring PEG and hexamethylene diisocyanate (HDI) contents, the elastomers X-P-mUs (X referred to the PEG content and m referred to HDI content) with a broad ranging mechanical properties and customized hydrophilicity were constructed. The X-P-mUs synthesized exhibited adjustable tensile Young's modulus, ultimate tensile strength and elongation at break in the range of 1.0 MPa-14.2 MPa, 0.3 MPa-7.6 MPa and 53.6%-272.8%, with the water contact angle varying from 28.6 degrees to 71.5 degrees, respectively. Accordingly, these elastomers showed favorable biocompatibility in vitro and mild host response in vivo. Furthermore, the potential applications of X-P-mU elastomers prepared with solvent-base and solvent-free techniques in biomedical fields were investigated. The results showed that these X-P-mU elastomers with high molding capacity at mild temperature could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity, demonstrating that the X-P-mU elastomers could be tailored as potential building blocks for diverse applications in biomedical research. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.