文献类型：期刊文献

英文题名：Copper(I)-mediated trifluoromethylthiolation of α-bromoketone with element sulfur and (trifluoromethyl)trimethylsilane

作者：Li, Jue[1];Xie, Fei-Fei[1];Wang, Peiqiang[1];Wu, Qiang-Yong[1];Chen, Wei-Dong[2];Ren, Jiangmeng[1];Zeng, Bu-Bing[1,2,3]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

年份：2015

卷号：71

期号：34

起止页码：5520

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000359033700011)，CCR-EXPANDED(收录号:WOS:000359033700011)】；

基金：We thank the National Natural Science Foundation of China (21302053) for the generous financial support. We are also grateful for the financial support from the Fundamental Research Funds for the Central University (WY111307).

语种：英文

外文关键词：Trifluoromethylthiolation; alpha-Bromoketone; Sulfur; (Trifluoromethyl)trimethylsilane

摘要：A new method has been developed for the copper(I)-mediated trifluoromethylthiolation of alpha-bromoketone using commercial anhydrous potassium fluoride, elemental sulfur, and (trifluoromethyl)-trimethylsilane in anhydrous N,N-dimethylformamide. This protocol provides facile access to a variety of alpha-trifluoromethylthiolated carbonyl compounds in moderate to excellent yields under mild and ligand free conditions. (C) 2015 Elsevier Ltd. All rights reserved.