文献类型：专利

英文题名：Resolving of racemic naproxen (R,S-naproxen) into S-(+)-naproxen comprises dissolving R,S-naproxen into resolving solvent, and adding certain amount of S-(-)-alpha-phenylethylamine at certain temperature

作者：SONG H;WEI Q;WU F;YANG X;YE W;ZHAO M

机构：[1]UNIV EAST CHINA SCI&TECHNOLOGY

申请号：CN102295551-A

申请日：2011-09-01

公开日：2011-12-28

语种：英文

收录：DERWENT

摘要：NOVELTY - Resolving of racemic naproxen (R,S-naproxen) into S-(+)-naproxen comprises dissolving R,S-naproxen into resolving solvent; adding certain amount of S-(-)- alpha -phenylethylamine at certain temperature; stirring and reacting for 30 minutes; filtering; washing cold resolving solvent to obtain salt; storing salt in water; acidifying until pH is 2.0-3.0; extracting by extracting agent; and removing extracting agent to obtain optically pure S-(+)-naproxen. USE - Resolving of racemic naproxen (R,S-naproxen) into S-(+)-naproxen. ADVANTAGE - The method provides S-(+)-naproxen with high optical purity, has (alpha)d equal to + 63.5 to + 65.0 degrees , preferably 63-68.5 degrees (at c=0.01, using chloroform at 25 degrees C). It provides 40% yield and uses low cost resolving agent.