文献类型：专利

英文题名：Thin film coating tablet comprises levetiracetam, silica micro powder as auxiliary agent, crosslinked sodium carboxymethyl cellulose as disintegrating agent, magnesium stearate as lubricant, starch slurry as adhesive and Opadry coating

作者：WU F;LI X;YAO Y;GUO L;LIN W

机构：[1]UNIV EAST CHINA SCI&TECHNOLOGY

申请号：CN102846576-A

申请日：2012-09-21

公开日：2013-01-02

语种：英文

收录：DERWENT

摘要：NOVELTY - A thin film coating tablet comprises 91.39-97.88 wt.% levetiracetam, 0.5-2 wt.% silica micro powder as auxiliary agent, 1-4 wt.% crosslinked sodium carboxymethyl cellulose as disintegrating agent, 0.1-1 wt.% magnesium stearate as lubricant, 0.49-1.70 wt.% starch slurry as adhesive and not greater than 3 wt.% Opadry coating. USE - Thin film coating tablet. ADVANTAGE - The tablet does not easily absorb moisture with good stability. The method has low cost, thus, saves production cost. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of thin film coating tablet comprising: (A) taking levetiracetam, passing through 80 meshes and weighing silica micro powder, crosslinked sodium carboxymethyl cellulose, magnesium stearate and starch slurry; (B) mixing uniformly, adding starch slurry granulation and sieving with 16, 18 or 20 meshes sieve, preferably 20 mesh sieve; (C) drying for 15 minutes at 50 degrees C and sieving to 16 meshes; (D) mixing, adding magnesium stearate, micropowder silica gel and mixing uniformly to obtain final mixing; and (E) putting into tablet sheet and coating Opadry coating to obtain tablet.