文献类型：期刊文献

英文题名：Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by α-cyclodextrin

作者：Huang, Lei[2];Chen, Jiaojiao[2];He, Muye[2];Hou, Xinyu[2];Lu, Yiben[2];Lou, Kaiyan[2,3];Gao, Feng[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2019

卷号：30

期号：1

起止页码：163

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000458344400037)】；

基金：This work was supported by Science and Technology Commission of Shanghai Municipality (Nos. 17ZR1406600, 10DZ2220500, 11DZ2260600) and National Natural Science Foundation of China (No.21577037).

语种：英文

外文关键词：alpha-Cyclodextrin; mPEG Grafted chitosan; Self-assembly; Nanoparticle; Drug delivery

摘要：This paper presented an interesting nanoparticle-based drug delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface, which is adjustable by addition of different amount of cyclodextrin (alpha-CD). The effect of alpha-CD inclusion to the self-assembly behavior of methoxy polyethylene glycol (mPEG) grafted chitosan (CS) was studied. The results showed that the mPEG grafted chitosan (mPEG-g-CS) forms self-assembled nanoparticles with either micelle or hollow sphere morphology depending on the ratio of alpha-CD to mPEG, as characterized by atomic force microscopy (AFM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). Their sizes and zeta potential increased from 257.6 nmto 768.2 nm and from +4.5 mV to +11.6 mV, respectively, with the increasing amount of alpha-CD. The correlation between zeta potential and particle size of alpha-CD/mPEG-g-CS nanoparticles indicated varied PEG density on surface of nanoparticles. Based on the above experimental observations, a likely mechanism for the morphological transition of the rod-coil graft copolymer mPEG-g-CS was proposed. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.