文献类型：期刊文献

英文题名：Simultaneous Occurrence of Psychotropic Pharmaceuticals in Surface Water of the Megacity Shanghai and Implication for Their Ecotoxicological Risks

作者：Liang, Jiahui[1];Meng, Haoyu[1];Zhou, Jie[1];Yin, Yue[2];Zhen, Huajun[2,3];Zhao, Yanbin[1,3];Zhang, Kun[1,3]

机构：[1]Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China;[2]East China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[3]Tongji Univ, Shanghai Inst Pollut Control & Ecol Secur, Shanghai 200092, Peoples R China

年份：2021

卷号：1

期号：4

起止页码：825

外文期刊名：ACS ES&T WATER

收录：WOS:【ESCI(收录号:WOS:000654124800009)】；

基金：Financial support from the Shanghai Pujiang Program [19PJ1404900] and the National Natural Science Foundation of China [21976121] is gratefully acknowledged.

语种：英文

外文关键词：Psychotropic Pharmaceuticals; Simultaneous Occurrence; Surface Water; Environmental Relevance; Ecotoxicological Risk

摘要：Psychotropic pharmaceuticals account for a large proportion of the most prescribed drugs globally. They cannot be completely removed in wastewater treatment plants (WWTPs), which raise a concern about their occurrence and ecotoxicology in the aquatic system. In the present study, we developed a sensitive and reliable method and analyzed 34 psychotropic pharmaceuticals in river water of the megacity Shanghai. The impacts of WWTPs on the contamination of psychoactive drugs were also evaluated by comparing the river water samples collected from upstream and downstream of WWTPs. Among the target substances, 29 drugs were detected in the water samples with the concentrations ranging from 0.03 to 260 ng/L, and the occurrence of five of them in river water was reported for the first time. Many psychotropic pharmaceuticals occurred in river water simultaneously with the total concentration up to 480 ng/L. The spatial distribution of psychotropic pharmaceuticals and the ratio between venlafaxine and its metabolite indicated the contamination of psychotropic pharmaceuticals was higher in populated areas but municipal WWTPs had little impact on their contaminations in the urban river of Shanghai, suggesting other important emission sources other than domestic wastewater exist. Exposure of zebrafish embryos further demonstrated multiple developmental effects caused by several of the most detected substances and, especially, by their mixtures and highlighted their interference with the neural development of zebrafish. Thus, our results provide novel insights into the understanding of the occurrence of psychotropic pharmaceuticals in surface waters and their ecotoxicological risks to aquatic organisms.