文献类型：期刊文献

英文题名：Retarded transport properties of graphene oxide based chiral separation membranes modified with dipeptide

作者：Gong, Huixue[1];Zhang, Shaoze[2,3,4];Liu, Nan[1];Zhang, Jingjing[1];Chen, Qibin[1];Liu, Honglai[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Kunming Univ Sci & Technol, Natl Engn Lab Vacuum Met, Kunming 650093, Yunnan, Peoples R China;[4]Kunming Univ Sci & Technol, Engn Lab Adv Battery & Mat Yunnan Prov, Kunming 650093, Yunnan, Peoples R China

年份：2022

卷号：288

外文期刊名：SEPARATION AND PURIFICATION TECHNOLOGY

收录：;EI(收录号：20220711649414);WOS:【SCI-EXPANDED(收录号:WOS:000784290100003)】；

基金：Acknowledgements This research is sponsored by National Natural Science Foundation of China (No. 21576079, 91834301, 22108111) , 111 Project of Ministry of Education of China (No. B08021) , Natural Science Foundation of Yunnan Province (202101AU070021) , Science Research Foundation of Education Department in Yunnan Province (2021 J0064) , and Natural Science Foundation of Kunming University of Science and Technology (KKZ3202052038) .

语种：英文

外文关键词：Graphene oxide; Enantioselectivity; Retarded transport; Membranes; High flux

摘要：The separation of racemates is still a great challenge, since enantiomers commonly exhibit identical physico-chemical properties in achiral environments, but differ in biological responses in chiral surroundings. Recently, graphene oxide (GO) based enantionseparation membranes had been proven to follow the facilitated or retarded transport mechanism, dependent on the choice of chiral selectors. Herein, a dipeptide was selected to act as the chiral selector for separating racemates, since it has a longer molecular length than single amino acids and two chiral centers as well, thus more potentially penetrating into the interlayer space in GO membranes. Results show that dipeptide-modified GO membranes exhibit a maximum separation factor of 1.85 with a 1-3 orders of magnitude improved flux in comparison to conventional chiral separation membranes, particularly a reversal of the transport mechanism from facilitated to retarded with respect to GO membranes previously reported. This is a likely consequence of the L-isomeric dipeptide that possesses a much stronger affinity toward the D-isomeric chiral analyte than the L-isomeric one due to the occurrence of extra nonstereoselective interaction between probes and the opposite GO substrate, so that such the dipeptide modified GO membrane exhibits a retarded transport mechanism, thereby offering a promise to achieve the continuous operation. These findings demon-strate that the extra nonstereoselective interaction plays a key role in the chiral recognition, especially in the confined space, and provides new opportunities for controlling the conversion from facilitated to retarded transport mechanisms and designing the novel enantioseparation membranes, aiming at the large-scale pro-duction of diversely pure enantiomers.