文献类型：期刊文献

英文题名：Characteristics of fast-spiking neurons in the striatum of behaving monkeys

作者：Yamada, Hiroshi[1,2,3,4];Inokawa, Hitoshi[1];Hori, Yukiko[1,5];Pan, Xiaochuan[6,7];Matsuzaki, Ryuichi[8];Nakamura, Kae[8,9];Samejima, Kazuyuki[6];Shidara, Munetaka[3,4];Kimura, Minoru[1,6];Sakagami, Masamichi[6];Minamimoto, Takafumi[1,5,9]

机构：[1]Kyoto Prefectural Univ Med, Dept Physiol, Kamigyo Ku, Kawaramachi Hirokoji, Kyoto 6028566, Japan;[2]Natl Ctr Neurol & Psychiat, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878502, Japan;[3]Univ Tsukuba, Div Biomed Sci, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan;[4]Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058577, Japan;[5]Natl Inst Radiol Sci, Mol Imaging Ctr, Dept Mol Neuroimaging, Chiba 2638555, Japan;[6]Tamagawa Univ, Brain Sci Inst, 6-1-1 Tamagawa Gakuen, Machida, Tokyo 1948610, Japan;[7]E China Univ Sci & Technol, Inst Cognit Neurodynam, Shanghai 200237, Peoples R China;[8]Kansai Med Univ, Dept Physiol, Shin Machi, Hirakata, Osaka 5701010, Japan;[9]Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

年份：2016

卷号：105

起止页码：2

外文期刊名：NEUROSCIENCE RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000375817800002)】；

基金：The authors wish to express their appreciation to M. Matsumoto and K. Seki. This research was supported by the Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science, and Technology, MEXT Japan (H.Y.: 15H05374, Y.H.: NO20900293) and by the Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology, MEXT Japan (M.S.: 23120001). X.P. is supported by National Natural Science Foundation of China (No. 11232005) and Shanghai Pujiang Program (13PJ1402000).

语种：英文

外文关键词：Basal ganglia; Inhibitory interneuron; Monkey; Reward

摘要：Inhibitory interneurons are the fundamental constituents of neural circuits that organize network outputs. The striatum as part of the basal ganglia is involved in reward-directed behaviors. However, the role of the inhibitory interneurons in this process remains unclear, especially in behaving monkeys. We recorded the striatal single neuron activity while monkeys performed reward-directed hand or eye movements. Presumed parvalbumin-containing GABAergic interneurons (fast-spiking neurons, FSNs) were identified based on narrow spike shapes in three independent experiments, though they were a small population (4.2%, 42/997). We found that FSNs are characterized by high-frequency and less-bursty discharges, which are distinct from the basic firing properties of the presumed projection neurons (phasically active neurons, PANs). Besides, the encoded information regarding actions and outcomes was similar between FSNs and PANs in terms of proportion of neurons, but the discharge selectivity was higher in PANs than that of FSNs. The coding of actions and outcomes in FSNs and PANs was consistently observed under various behavioral contexts in distinct parts of the striatum (caudate nucleus, putamen, and anterior striatum). Our results suggest that FSNs may enhance the discharge selectivity of postsynaptic output neurons (PANs) in encoding crucial variables for a reward-directed behavior. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.