文献类型：期刊文献

英文题名：Chiral Separation of Menthol Enantiomers by Simulated Moving Bed Chromatography: Mathematical Modeling and Experimental Study

作者：Sun, Linhe[1,2];Yang, Ying[1,2];Yu, Jianguo[1,2]

机构：[1]East China Univ Sci & Technol, Natl Engn Res Ctr Integrated Utilizat Salt Lake Re, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Resources Proc Engn, Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2026

卷号：13

期号：2

外文期刊名：SEPARATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001701132900001)】；

基金：This work was funded by the National Key R&D Program of China [2023YFB4104000], the Key Research and Development Program of Jiang-xi Province [20223BBG74008], and ECUST-Jinghao Salt Chemical Carbon and Calcium Cycles Joint Research Centre.

语种：英文

外文关键词：l-menthol; chiral separation; liquid chromatography; chiral stationary phase; simulated moving bed; mathematical modeling

摘要：l-menthol is one of the most popular flavors in the world. The separation of menthol enantiomers is crucial because of the unpleasant taste of d-menthol. This work presents the chiral separation of racemic menthol by simulated moving bed chromatography for the first time. Six preparative columns packed with amylose 3,5-dimethylphenylcarbamate coated on silica gel were used for separation, and a mixture of n-hexane/isopropanol was selected as the mobile phase. The hydrodynamic properties of the SMB columns were studied to minimize the packing asymmetry in the SMB experiment. The binary adsorption isotherm of menthol enantiomers was measured by the adsorption-desorption method. Fixed-bed batch chromatography was carried out to evaluate the adsorption kinetic behavior. Mathematical models, considering the mass transfer resistance and axial dispersion, were applied to describe the dynamics of the chromatographic separation process. The SMB process for chiral separation of racemic menthol was designed by evaluating the separation region using simulations. Reasonable agreements were achieved between the predicted results and the experimental results. Purities for both the extract and raffinate were above 99.0%, and a productivity of 0.267 gracemate/(LCSP center dot min) and a solvent consumption of 0.431 L/gracemate were achieved.