文献类型：期刊文献

英文题名："Crossbreeding" NIR-II flavchromene for PSMA-positive prostate cancer detection and image-guided surgery

作者：Huang, Jialiang;Yao, Yongkang;Zhang, Liao;Yan, Chenxu;Guo, Zhiqian[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, State Key Lab Bioreactor Engn,Key Lab Adv Mat,Feri, Shanghai, Peoples R China; East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn,Feringa N, Shanghai, Peoples R China

年份：2024

卷号：2

期号：3

外文期刊名：SMART MOLECULES

收录：WOS:【ESCI(收录号:WOS:001498786400001)】；

基金：This work was supported by NSFC/China (22225805, 21878087, 22378122, 32394001, and 32121005), National Key Research and Development Program (2021YFA0910000), Shanghai Science and Technology Innovation Action Plan (No. 23J21901600), Innovation Program of Shanghai Municipal Education Commission, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28), Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), Shanghai Science and Technology Committee Rising-Star Program (22QC1400400) and Programme of Introducing Talents of Discipline to Universities (B16017), Natural Science Foundation of Shanghai (23ZR1416600).

语种：英文

外文关键词：fluorescence dyes; near-infrared; NIR-II fluorescence imaging; PSMA-targeting

摘要：Prostate-specific membrane antigen (PSMA) is known to be overexpressed in prostate cancer (PCa). The development of precise and rapid imaging technologies to monitor PSMA is crucial for early diagnosis and therapy. Fluorescence imaging in the second near-infrared window (NIR-II) has emerged as a powerful tool for real-time tracking and in vivo visualization, offering high sensitivity and resolution. However, there is a lack of stable, bright and easy-to-implement NIR-II fluorescent probes for PSMA targeting. Herein, we presented a PSMA-targeting NIR-II fluorescent probe FC-PSMA based on pi-conjugated crossbreeding dyed strategy that affords high stability, large extinction coefficient, and good brightness. As demonstrated, FC-PSMA displayed a high fluorescence quantum yield in fetal bovine serum (FBS). Following intravenous injection of FC-PSMA, the tumor-to-normal ratio of fluorescence intensity steadily increased over time, reaching a peak at 48 h (tumor-to-leg ratio = 12.16 +/- 0.90). This advancement enables precise identification of PC through NIR-II fluorescence imaging, facilitating high-performance guidance for prostate cancer resection surgery.