文献类型：期刊文献

英文题名：Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties

作者：Wang, Ruixiao[1];Liu, Liqun[1];He, Xiang[1,2];Xia, Zongmei[1];Zhao, Zhenjie[1];Xi, Zhenhao[1,2];Yu, Juan[1];Wang, Jie[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：15

期号：8

外文期刊名：POLYMERS

收录：;EI(收录号：20231814040953);WOS:【SCI-EXPANDED(收录号:WOS:000976840100001)】；

基金：This work was supported by the National Natural Science Foundation of China (21978089 and 51403062).

语种：英文

外文关键词：tissue adhesive; in situ hydrogel; hyaluronic acid; carboxymethyl chitosan

摘要：The non-invasive tissue adhesives with strong tissue adhesion and good biocompatibility are ideal for replacing traditional wound treatment methods such as sutures and needles. The self-healing hydrogels based on dynamic reversible crosslinking can recover their structure and function after damage, which is suitable for the application scenario of tissue adhesives. Herein, inspired by mussel adhesive proteins, we propose a facile strategy to achieve an injectable hydrogel (DACS hydrogel) by grafting dopamine (DOPA) onto hyaluronic acid (HA) and mixing it with carboxymethyl chitosan (CMCS) solution. The gelation time and rheological and swelling properties of the hydrogel can be controlled conveniently by adjusting the substitution degree of the catechol group and the concentration of raw materials. More importantly, the hydrogel exhibited rapid and highly efficient self-healing ability and excellent biodegradation and biocompatibility in vitro. Meanwhile, the hydrogel exhibited similar to 4-fold enhanced wet tissue adhesion strength (21.41 kPa) over the commercial fibrin glue. This kind of HA-based mussel biomimetic self-healing hydrogel is expected to be used as a multifunctional tissue adhesive material.