文献类型：期刊文献

英文题名：Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point

作者：Yao, Yi-Chen[1]; Jin, Zhe[1]; Hong, Minghuang[1]; Zhu, Bin[1]; Ren, Guo-Bin[1]; Qi, Ming-Hui[1]

机构：[1] Laboratory of Pharmaceutical Crystal Engineering & Technology, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, No. 130 Meilong Road, Shanghai, 200237, China

年份：2024

卷号：24

期号：1

起止页码：554

外文期刊名：Crystal Growth and Design

收录：EI(收录号：20235115246660)

语种：英文

外文关键词：Melting point - Single crystals - Surface analysis - Thermoanalysis

摘要：Levamisole hydrochloride cocrystallizes with hydroquinone in different solvates (methanol, ethanol, water, acetonitrile, and n-propanol), forming the changing Z″ cocrystal solvates from 23 to 3.33. These cocrystals were characterized by using single-crystal and powder X-ray diffraction and thermal analysis. All cocrystal solvates consist of different 2D planar sheets, which influence the Z″ value and melting point. The findings suggest a method for obtaining high Z crystals through suitable solvents. Topology analysis and Hirshfeld surface analysis were conducted to understand the Z″ transformation. Further, quantum chemistry was demonstrated as a significant tool to explain the extremely low melting point and the change of the melting point in different solid forms. ? 2023 American Chemical Society.