文献类型：期刊文献

英文题名：Efficient P-Chiral Biaryl Bisphosphorus Ligands for Palladium-Catalyzed Asymmetric Hydrogenation

作者：Jiang, Wenhao[1];Zhao, Qing[2];Tang, Wenjun[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, 130 Meilong Rd, Shanghai 200037, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2018

卷号：36

期号：2

起止页码：153

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000419774400011)，CCR-EXPANDED(收录号:WOS:000419774400011)】；

基金：The work is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20000000), CAS (QYZDY-SSW-SLH029), the National Natural Science Foundation of China (Nos. 21432007, 21572246, 21725205) and K. C. Wong Education Foundation.

语种：英文

外文关键词：biaryl bisphosphorus ligands; asymmetric hydrogenation; enantioselectivity; palladium; P-chiral

摘要：A series of structurally novel P-chiral biaryl bisphosphorus ligands L1-L5 (BABIBOPs) are developed, providing high efficiency for the first time in palladium-catalyzed asymmetric hydrogenation of -aryl and -alkyl substituted -keto esters. With the Pd-L3 (iPr-BABIBOP) catalyst, a series of chiral -hydroxyl carboxylic esters are formed in excellent enantioselectivities (up to>99% ee) and yields at catalyst loading as low as 0.01 mol%.