文献类型：期刊文献

英文题名：High yield synthesis of D-phenylglycine and its derivatives by nitrilase mediated dynamic kinetic resolution in aqueous-1-octanol biphasic system

作者：Qiu, Jian[1];Su, Erzheng[1,2];Wang, Wei[1];Wei, Dongzhi[1]

机构：[1]E China Univ Sci & Technol, New World Inst Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Nanjing Forestry Univ, Coll Light Ind Sci & Engn, Enzyme & Fermentat Technol Lab, Nanjing 210037, Jiangsu, Peoples R China

年份：2014

卷号：55

期号：8

起止页码：1448

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000332432300015)】；

基金：This work was supported by the National Basic Research Program of China (No. 2012CB721003), the Fundamental Research Funds for the Central Universities and the National Major Science and Technology Projects of China (No.2012ZX09304009).

语种：英文

外文关键词：Nitrilase; Dynamic kinetic resolution; Biphasic system; D-Phenylglycine

摘要：A strategy of nitrilase mediated dynamic kinetic resolution toward the synthesis of D-phenylglycine was developed, using aqueous-l-octanol biphasic system. Due to the efficient suppression of the decomposition of phenylglycinonitrile, a maximum yield of 81% is obtained. This result indicates that the nitrilase mediated dynamic kinetic resolution is a promising method toward the synthesis of D-phenylglycine and its derivatives. (C) 2014 Elsevier Ltd. All rights reserved.