文献类型：期刊文献

英文题名：Determination and correlation of solubility and mixing properties of isonicotinamide (form II) in some pure solvents

作者：Li, Bingxue[1];Wu, Yanyang[1];Zhu, Jiawen[1];Chen, Kui[1];Wu, Bin[1];Ji, Lijun[1]

机构：[1]E China Univ Sci & Technol, Chem Engn Res Ctr, Shanghai 200237, Peoples R China

年份：2016

卷号：627

起止页码：55

外文期刊名：THERMOCHIMICA ACTA

收录：;EI(收录号：20161102083127);WOS:【SCI-EXPANDED(收录号:WOS:000374075400007)】；

基金：The financial support of the Fundamental Research Funds for the Central Universities is gratefully acknowledged.

语种：英文

外文关键词：Isonicotinamide; Solubility; Correlation; Mixing properties; Inter-molecular interaction

摘要：Solubility data were determined for isonicotinamide in water, ethanol, 2-propanol, n-butanol, 2-butanol, ethyl acetate and butyl acetate from 298.15 to 323.15 K with a static analytic method. The Van't Hoff equation, modified Apelblat equation, lambda h (Buchowski) equation and two local composition models (NRTL and UNIQUAC) were used to correlate the solubility data, and modified Apelblat equation shows the best agreement among all the five models. Besides, differential scanning calorimetry were used to determine the crystal forms crystallized in the seven solvents and obtain the melting temperature T-m and fusion enthalpy Delta H-fus(m). Furthermore, the activity coefficients of isonicotinamide and mixing Gibbs free energies, enthalpies, and entropies of the solutions were predicted. All solutions studied exhibit high non-ideality, indicating the important role of homo-molecules interactions for solubility behavior. The dissolution enthalpies and entropies were also estimated in this work. (C) 2016 Elsevier B.V. All rights reserved.