文献类型：期刊文献

英文题名：Derivatives of benzothiadiazole-7-carboxylates: synthesis and biological activity

作者：Zhu, Weiping[1,2];Zhao, Zhenjiang[1,2];Xu, Yufang[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Key Lab Chem Biol, Shanghai, Peoples R China

年份：2008

卷号：139

期号：9

起止页码：1067

外文期刊名：MONATSHEFTE FUR CHEMIE

收录：;EI(收录号：20242616455196);WOS:【SCI-EXPANDED(收录号:WOS:000258843600013)】；

基金：This work was under the auspices of The National Basic Research Program of China (2003CB114400), National Natural Science Foundation of China, The Science and Technology Foundation of Shanghai, Program of Shanghai Subject Chief Scientist and The Shanghai Leading Academic Discipline Project ( Project Number: B507).

语种：英文

外文关键词：jasmonate; benzothiadiazole-7-carboxylates; hydrogen peroxide; biological activity

摘要：Salicylic acid (SA) and methyl jasmonate (MJ) are important plant signal molecules to cause systemic acquired resistance (SAR), while it's reported that they also have wide spectrum antitumor activities. Benzothiadiazole-7-carboxylates are plant activators which can cause SAR just like SA and MJ. To investigate whether the benzothiadiazole-7-carboxylate family is endowed with anticancer activities, several benzothiadiazole-7-carboxylate derivatives are synthesized and their inhibition to P388 murine leukemia cell and A549 human lung cancer cell compared with MJ are evaluated. The data indicated that benzo-1,2,3-thiadiazole-7-carboxylic acid 2-benzoyloxyethyl ester has a higher inhibition ability to the cancer cell P388 and A549, compared with MJ.