文献类型：期刊文献

英文题名：Injectable Self-Healing and Anti-Dissolving Low-Molecular-Weight Hydrogels Enabled by Ionic Cross-Linking for Cell Encapsulation

作者：Zhang, Jiahao[2];Jin, Kaiyu[2];Feng, Yifei[2];Lu, Da[2];Chen, Mai[2];Wang, Hucheng[2];Jin, Cheng[1];Wang, Dengyu[1];Li, Zhiling[1];Wang, Yiming[2,3]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Pharm, Shanghai 200127, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Intelligent Sensing & Detect Tech, Shanghai 200237, Peoples R China

年份：2024

卷号：14

期号：1

起止页码：20

外文期刊名：ACS MACRO LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001379939400001)】；

基金：We acknowledge the financial support of the Fundamental Research Funds for the Central Universities (YG2023LC13), Science and Technology Commission of Shanghai Municipality (23430761100), Shanghai Pilot Program for Basic Research (22TQ1400100-9), Natural Science Foundation of Shanghai (22ZR1417700), Natural Science Foundation of China (21908061), and National Key Research and Development Program of China (2022YFD70050101).

语种：英文

摘要：Injectable behavior is often observed in polymer-based hydrogels yet is rarely achieved in low-molecular-weight hydrogels (LMWHs), the realization of which may boost the development of new soft materials for biomedical applications. Here, we report on injectable self-healing and antidissolving LMWHs that are formed through a simple ionic cross-linking strategy, showing a fundamental application for the encapsulation of living cells. The LMWHs are formed by simply mixing Ca2+ with negatively charged supramolecular polymers. Surprisingly, the resultant hydrogels are capable of rapidly self-healing within seconds after damage, showing an unexpected injectable function. When the hydrogel is injected into an aqueous medium, continuous macroscopic hydrogel fibers can be produced. Interestingly, the hydrogel can remain intact in the aqueous medium, showing impressive antidissolving behavior which is less observed in other LMWHs. Furthermore, the hydrogel is demonstrated to be nontoxic and can be used as a cytocompatible scaffold for living cells. This work may open an avenue toward injectable and antidissolving LMWHs for the ever-expanding list of applications in biotherapy and bioprinting.