文献类型：期刊文献

英文题名：Taking Orders from Light: Photo-Switchable Working/Inactive Smart Surfaces for Protein and Cell Adhesion

作者：Zhang, Junji[1];Ma, Wenjing;He, Xiao-Peng[1];Tian, He

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：9

期号：10

起止页码：8498

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20171203473767);WOS:【SCI-EXPANDED(收录号:WOS:000396801200010)】；

基金：This research is supported by the 973 project (2013CB733700), the National Natural Science Foundation of China (21402050, 21420102004, and 21572058), the Programme of Introducing Talents of Discipline to Universities (B16017), and the Shanghai Rising-Star Program (16QA1401400 to X.-P.H.). Prof. Jia Li and Prof. Yi Zang at Shanghai Institute of Materia Medica are warmly thanked for their help in cellular experiments. Dr. Xin Hua is warmly thanked for her help in TOF-SIMS.

语种：英文

外文关键词：photoswitching; self-assembled monolayer; azobenzene; monosaccharide protein recognition; cell adhesion

摘要：Photoresponsive smart surfaces are promising candidates for a variety of applications in optoelectronics and sensing devices. The use of light as an order signal provides advantages of remote and noninvasive control with high temporal and spatial resolutions. Modification of the photoswitches with target biomacromolecules, such as peptides, DNA, and small molecules including folic acid derivatives and sugars, has recently become a popular strategy to empower the smart surfaces with an improved detection efficiency and specificity. Herein, we report the construction of photoswitchable self-assembled monolayers (SAMs) based on sugar (galactose/mannose)-decorated azobenzene derivatives and determine their photoswitchable, selective protein/cell adhesion performances via electrochemistry. Under alternate UV/vis irradiation, interconvertible high/low recognition and binding affinity toward selective lectins (proteins that recognize sugars) and cells that highly express sugar receptors are achieved. Furthermore, the cis-SAMs with a low binding affinity toward selective proteins and cells also exhibit minimal response toward unselective protein and cell samples, which offers the possibility in avoiding unwanted contamination and consumption of probes prior to functioning for practical applications. Besides, the electrochemical technique used facilitates the development of portable devices based on the smart surfaces for on-demand disease diagnosis.