文献类型：期刊文献

英文题名：Synthesis of γ,γ-difluoro-β-hydroxy-δ-lactones as new precursors of HMG-CoA reductase inhibitor

作者：Wang, Xiaoguang[1,2];Fang, Xiang[1,2];Xiao, Hongyuan[1,2];Yin, Yan[3];Xia, Huimin[1,2];Wu, Fanhong[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 200235, Peoples R China

年份：2012

卷号：133

起止页码：178

外文期刊名：JOURNAL OF FLUORINE CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000300469500028)】；

基金：The authors thank the National Natural Science Foundation of China (No. 20972050 and No. 21172148) and Science and Technology Commission of Shanghai Municipality (No. 10540501300) for financial support.

语种：英文

外文关键词：Statin; HMG-CoA reductase inhibitor; Precursor; gamma,gamma-Difluoro-beta-hydroxy-delta-lactones

摘要：A series of gamma,gamma-difluoro-beta-hydroxy-delta-lactones 1 were efficiently synthesized as new precursors of HMG-CoA reductase inhibitor in one pot by treatment of readily prepared gem-difluoromethylenated acetonides 3 with trifluoroacetic acid. Contrarily, acetonides 3 could be transformed to the gamma,gamma-gem-difluoromethylenated alpha,beta-unsaturated delta-lactones 2 through hydrolyzation and lactonization in refluxing toluene. (C) 2011 Elsevier B.V. All rights reserved.