文献类型：期刊文献

英文题名：Recent Advances in Transition-Metal-Catalyzed Asymmetric Functionalization of Enamides

作者：Xi, Yang;Chen, Yifeng[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Adv Mat, Sch Chem & Mol Engn,Feringa Nobel Prize Scientist, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Joint Int Res Lab Precis Chem & Mol Engn, Sch Chem & Mol Engn,Feringa Nobel Prize Scientist, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：54

期号：21

起止页码：4646

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20223012422168);WOS:【SCI-EXPANDED(收录号:WOS:000841546700001)】；

基金：This work was supported by NSFC/China (22171079), Natural Science Foundation of Shanghai (21ZR1480400), Shanghai Rising-Star Program (20QA1402300), Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03), the Program of Introducing Talents of Discipline to Universities (B16017), the Fundamental Research Funds for the Central Universities (222201717003).

语种：英文

外文关键词：enamides; asymmetric catalysis; Heck reaction; hydro-functionalization; difunctionalization

摘要：Enamides, as prefunctionalized electron-rich heteroatomsubstituted alkenes represent a powerful platform to synthesize useful nitrogen-containing natural products and bioactive molecules. This review discloses recent progress in the transition-metal-catalyzed enantioselective functionalization of enamides, including the Heck reaction, hydrofunctionalization, and difunctionalization, with a focus on the general scope, current limitations, stereochemical reaction control, and mechanistic aspects.