文献类型：期刊文献

英文题名：Preparation, microstructure and function for injectable liposome-hydrogels

作者：Xu, Shiju[1];An, Xueqin[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：560

起止页码：20

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20184105914149);WOS:【SCI-EXPANDED(收录号:WOS:000451048400003)】；

基金：This research was supported by the National Natural Science Foundation of China (21473055 and 21773064).

语种：英文

外文关键词：Thermosensitive; Liposome-hydrogels; Injectable hydrogel; Microstructure; Saturated concentration

摘要：A novel injectable liposome-hydrogels was prepared by combined methods of thin-film evaporation and supercritical carbon dioxide technique (TE-scCO(2)) for drug delivery of tissue regeneration. The liposome-hydrogels with thermosensitive is colloidal sol at room temperature, but it is gel at body temperature. Therefore, the thermosensitive liposome-hydrogels can get into the target area by injecting process at room temperature, and it will convert to gel at body temperature. In curcumin liposome-hydrogels (Cur-Lps-H), curcumin (Cur) as model drug was loaded in liposomes and the liposome was embedded in three-dimensional porous chitosan/beta-glycerophosphate hydrogel. The microstructure of Cur-Lps-H was studied by using pyrene and 1,6-diphenyl-1,3,5-hexatriene (DPH) as fluorescent probes, and it was found that Cur was entrapped in bilayer of liposomes and its saturated concentration in bilayer of liposomes was about 0.012 (mass ratio of Cur to lecithin). The Cur-Lps-H prepared by TE-scCO(2) method had higher entrapment efficiency and better stability in comparasion with that prepared by thin film hydration (FH). Moreover, the Cur-Lps-H possessed obviously sustained-release effect (extend to 12 days) in vitro, which was longer than other drug delivery system. Therefore injectable liposome-hydrogels is a potential drug delivery system.